SrasV1, Main, Exploration, bibRecord, 002A39

Recombination, Reservoirs, and the Modular Spike: Mechanisms of Coronavirus Cross-Species Transmission▿

Identifieur interne : 002A39 ( Main/Exploration ); précédent : 002A38; suivant : 002A40

Recombination, Reservoirs, and the Modular Spike: Mechanisms of Coronavirus Cross-Species Transmission▿

Auteurs : Rachel L. Graham ; Ralph S. Baric

Source :

Journal of Virology [ 0022-538X ] ; 2009.

RBID : PMC:2838128

Descripteurs français

KwdFr :
- Animaux, Données de séquences moléculaires, Fréquence d'allèle, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (), Glycoprotéines membranaires (physiologie), Humains, Protéines de fusion virale (), Protéines de fusion virale (physiologie), Protéines de l'enveloppe virale (), Protéines de l'enveloppe virale (physiologie), Recombinaison génétique, Récepteurs viraux (physiologie), Réservoirs d'agents pathogènes (virologie), Sites de fixation, Spécificité d'espèce, Syndrome respiratoire aigu sévère (transmission), Séquence d'acides aminés, Tropisme viral, Virus du SRAS (génétique).
MESH :
- génétique : Virus du SRAS.
- physiologie : Glycoprotéines membranaires, Protéines de fusion virale, Protéines de l'enveloppe virale, Récepteurs viraux.
- virologie : Réservoirs d'agents pathogènes.
- Animaux, Données de séquences moléculaires, Fréquence d'allèle, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires, Humains, Protéines de fusion virale, Protéines de l'enveloppe virale, Recombinaison génétique, Sites de fixation, Spécificité d'espèce, Syndrome respiratoire aigu sévère, Séquence d'acides aminés, Tropisme viral.

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Binding Sites, Disease Reservoirs (virology), Gene Frequency, Humans, Membrane Glycoproteins (chemistry), Membrane Glycoproteins (physiology), Molecular Sequence Data, Receptors, Virus (physiology), Recombination, Genetic, SARS Virus (genetics), Severe Acute Respiratory Syndrome (transmission), Species Specificity, Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (physiology), Viral Fusion Proteins (chemistry), Viral Fusion Proteins (physiology), Viral Tropism.
MESH :
- chemical , chemistry : Membrane Glycoproteins, Viral Envelope Proteins, Viral Fusion Proteins.
- chemical , physiology : Membrane Glycoproteins, Receptors, Virus, Viral Envelope Proteins, Viral Fusion Proteins.
- genetics : SARS Virus.
- transmission : Severe Acute Respiratory Syndrome.
- virology : Disease Reservoirs.
- Amino Acid Sequence, Animals, Binding Sites, Gene Frequency, Humans, Molecular Sequence Data, Recombination, Genetic, Species Specificity, Spike Glycoprotein, Coronavirus, Viral Tropism.

Abstract

Over the past 30 years, several cross-species transmission events, as well as changes in virus tropism, have mediated significant animal and human diseases. Most notable is severe acute respiratory syndrome (SARS), a lower respiratory tract disease of humans that was first reported in late 2002 in Guangdong Province, China. The disease, which quickly spread worldwide over a period of 4 months spanning late 2002 and early 2003, infected over 8,000 individuals and killed nearly 800 before it was successfully contained by aggressive public health intervention strategies. A coronavirus (SARS-CoV) was identified as the etiological agent of SARS, and initial assessments determined that the virus crossed to human hosts from zoonotic reservoirs, including bats, Himalayan palm civets (Paguma larvata), and raccoon dogs (Nyctereutes procyonoides), sold in exotic animal markets in Guangdong Province. In this review, we discuss the molecular mechanisms that govern coronavirus cross-species transmission both in vitro and in vivo, using the emergence of SARS-CoV as a model. We pay particular attention to how changes in the Spike attachment protein, both within and outside of the receptor binding domain, mediate the emergence of coronaviruses in new host populations.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838128

DOI: 10.1128/JVI.01394-09
PubMed: 19906932
PubMed Central: 2838128

Affiliations:

Le document en format XML

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<term>Gene Frequency</term>
<term>Humans</term>
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<term>Membrane Glycoproteins (physiology)</term>
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<term>Viral Tropism</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Données de séquences moléculaires</term>
<term>Fréquence d'allèle</term>
<term>Glycoprotéine de spicule des coronavirus</term>
<term>Glycoprotéines membranaires ()</term>
<term>Glycoprotéines membranaires (physiologie)</term>
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<term>Protéines de fusion virale (physiologie)</term>
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<term>Séquence d'acides aminés</term>
<term>Tropisme viral</term>
<term>Virus du SRAS (génétique)</term>
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<term>Viral Fusion Proteins</term>
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<term>Récepteurs viraux</term>
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<term>Binding Sites</term>
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<term>Molecular Sequence Data</term>
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<front><div type="abstract" xml:lang="en"><p>Over the past 30 years, several cross-species transmission events, as well as changes in virus tropism, have mediated significant animal and human diseases. Most notable is severe acute respiratory syndrome (SARS), a lower respiratory tract disease of humans that was first reported in late 2002 in Guangdong Province, China. The disease, which quickly spread worldwide over a period of 4 months spanning late 2002 and early 2003, infected over 8,000 individuals and killed nearly 800 before it was successfully contained by aggressive public health intervention strategies. A coronavirus (SARS-CoV) was identified as the etiological agent of SARS, and initial assessments determined that the virus crossed to human hosts from zoonotic reservoirs, including bats, Himalayan palm civets (<italic>Paguma larvata</italic>
), and raccoon dogs (<italic>Nyctereutes procyonoides</italic>
), sold in exotic animal markets in Guangdong Province. In this review, we discuss the molecular mechanisms that govern coronavirus cross-species transmission both <italic>in vitro</italic>
 and <italic>in vivo</italic>
, using the emergence of SARS-CoV as a model. We pay particular attention to how changes in the Spike attachment protein, both within and outside of the receptor binding domain, mediate the emergence of coronaviruses in new host populations.</p>
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Serveur d'exploration SRAS

Recombination, Reservoirs, and the Modular Spike: Mechanisms of Coronavirus Cross-Species Transmission▿

Recombination, Reservoirs, and the Modular Spike: Mechanisms of Coronavirus Cross-Species Transmission▿

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
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